抗生素 MS-444
BE-34776(MS-444)
CAS: 150045-18-4
化学式: C13H10O4
| 中文名 | BE-34776 |
| 英文名 | MS-444 |
| 别名 | 抗生素 MS-444 化合物 T16145 |
| 英文别名 | MS-444 BE-34776 5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone Naphtho[2,3-c]furan-4(9H)-one, 5,8-dihydroxy-3-methyl- |
| CAS | 150045-18-4 |
| 化学式 | C13H10O4 |
| 分子量 | 230.22 |
| 密度 | 1.452±0.06 g/cm3(Predicted) |
| 沸点 | 448.7±45.0 °C(Predicted) |
| 酸度系数 | 8.14±0.20(Predicted) |
| 存储条件 | 2-8°C，密封，干燥 |
| 体外研究 | MS-444 is a small molecule RNA-binding protein HuR (ELAVL1) inhibitor. Colorectal cancer (CRC) cells that display HuR overexpression are treated with MS-444 (1-100 μM) for 48 hr with IC 50 s of 10.98±1.76 μM, 12.84±2.10 μM, 5.60±0.90 μM, 14.21±2.11 μM, and 10.98±1.24 μM for HCT116, HCA-7, RKO, HT-29, and SW480 cells, respectively. Growth inhibition is observed in all CRC lines with IC 50 values ranging from 5.60 μM to 14.21 μM with observable effects seen at 10 μM MS-444. Contrasting effects are observed using non-transformed small intestinal (RIE-1 (IC 50 =40.70±3.53 μM)) and colonic (YAMC (IC 50 =28.16±3.23 μM)) epithelial cells. Both cell types display properties of normal intestinal epithelial cells and are proficient in 3′UTR AU-rich elements (ARE)-mRNA decay. Both non-transformed cell lines are ~3- to 4-fold less responsive to MS-444-mediated growth inhibition, with IC 50 values of 40.70 μM and 28.16 μM ( P <0.05). |
| 体内研究 | To test the effects of MS-444 on CRC cell growth in vivo, mice bearing HCT116 cell xenografts receive IP injections of MS-444 (25 mg/kg bw) or vehicle every 48 hr. Over the experiment course, mice do not display any adverse effects and maintained similar weights. Anti-tumor effects of MS-444 are observed with approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 show a marked 2- to 3-fold decrease in microvessel density (MVD), indicating the anti-angiogenic potential of MS-444. |
抗生素 MS-444 - 简介
可能是因为该化合物较为新颖或较少被研究。
最后更新：2024-04-10 22:29:15
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